Application Event 1530 causes system to hang or randonly reboot

Has anyone encountered this problem with Vista 64 ?

Windows detected your registry file is still in use by other applications or
services. The file will be unloaded now. The applications or services that
hold your registry file may not function properly afterwards.

DETAIL -
1 user registry handles leaked from
\Registry\User\S-1-5-21-3376204333-2807467392-4250138775-1000_Classes:
Process 828 (\Device\HarddiskVolume1\Windows\System32\svchost. exe) has
opened key
\REGISTRY\USER\S-1-5-21-3376204333-2807467392-4250138775-1000_CLASSES

---------------------------------------
Log Name: Application
Source: User Profile Service
Event ID: 1530
Level: Warning
User: SYSTEM
OpCode: Info
Task Category: None
Keywords: Classic