Good Reimaging practice?

We are currently using Ghost to image our desktops and laptops. We move our
user profile to a separate drive than the C drive so that we can re image the
laptop without having to back up all of the data.

With ghost we run sysprep and then immediatly save the image up to our
servers. Well with sysprep we can't reimage just the c drive without sysprep
running every time and deleting the data.

Is there a better way to save the profile information on a different drive
and be able to reimage the C drive?