You might try right clicking and run as administrator.

"Dave Boomhauer" <daveboomhauer@yahoo.co.uk> wrote in message
news:upqdxXdTHHA.4632@TK2MSFTNGP04.phx.gbl...
>I have just installed Photoshop CS on Vista Ultimate x64
>
> The program opens, but stalls whilst loading plugins etc and says the
> program cannot be opened as the file is locked.
>
> Use the properties tab to unlock the program.......
>
> Anyone else had this and know what to do?